Trimetazidine (nama lain Vastarel)

Common use

Vastarel (trimetazidine) is used to treat angina (chest pain) and improve heart function in patients with heart disease. It works by increasing the efficiency of the heart muscle, helping it use oxygen more effectively, and reducing the frequency of angina attacks. Vastarel is also sometimes used in the management of conditions like dizziness and tinnitus caused by poor blood circulation.

Dosage and direction

Swallow the pill whole with a glass of water. Do not chew, crush or break the pill. Always consult your doctor for specific details and advice on how to use this medicine.

Precautions

Caution is advised while taking Vastarel if you are pregnant. It is best to consult your doctor before taking this medicine.
The safety of Vastarel during breastfeeding has not been established. Consult your doctor to understand the potential risks and benefits.
This medicine is often prescribed for older patients, who may be more susceptible to liver health issues. It's advisable to discuss liver-related concerns with your doctor before starting treatment with Vastarel.
Caution is advised before using Vastarel if you have a history of any kidney problems. It is a good idea to consult your doctor before taking this medicine.

Contraindications

Vastarel is contraindicated in patients with a history of hypersensitivity to Trimetazidine. It is also contraindicated in patients with Parkinson's disease, parkinsonian symptoms, tremors, restless leg syndrome, and other movement disorders. It is also contraindicated in patients with severe renal impairment.
Vastarel should not be taken if you have a known allergy to trimetazidine or any other ingredients. If you have a history of allergies, inform your doctor before starting this medication.

Possible side effect

Vastarel may cause the following side effects: Dizziness; Headache; Stomach pain; Diarrhea; Skin rash; Thrombocytopenia: This is a condition where your blood has a lower-than-normal number of platelets, which are needed for clotting; Agranulocytosis: This is a serious condition where the body does not have enough white blood cells, which fight infections; Liver dysfunction: This refers to problems with the functioning of the liver.

Drug interaction

CYP2D6 Inhibitors: Medicines like fluoxetine, paroxetine, and propafenone may increase the levels of Vastarel in your body.
Antihypertensive Agents: Medicines such as amlodipine or lisinopril may have their blood pressure-lowering effects enhanced when taken with Vastarel.
Beta-Blockers: When taken with Vastarel, beta-blockers like propranolol may have an increased effect on slowing down your heart rate.

Missed dose

If you forget to take a dose of Vastarel, take it as soon as you remember. If it's nearly time for your next dose, skip the missed one and continue with your regular schedule.

Overdose

If you accidentally take more than the prescribed dose of Vastarel, you may experience common side effects like dizziness or stomach pain. If these symptoms persist, inform your doctor.

Storage

Store Vastarel at room temperature between 15 and 30°C. Protect it from light and moisture; keep it in a tightly closed container. Keep this medicine out of children's reach. Always check the expiry date on the label before use.